Antiepileptic Drug Disposition in Pregnancy
نویسندگان
چکیده
منابع مشابه
Antiepileptic drugs: Energy-consuming processes governing drug disposition.
Diffusion is not the main process by which drugs are disposed throughout the body. Translational movements of solutes given by different energy-consuming mechanisms are required in order to dispose them efficiently. Membrane transportation and cardiac output distribution are two effective processes to move the molecules among different body sites. Gastrointestinal-blood cycling constitutes a su...
متن کاملNorth American antiepileptic drug pregnancy registry.
Background: The North American AED (antiepileptic drug) Pregnancy Registry was established in 1997 for pregnant women in the United States and Canada at the Massachusetts General Hospital in Boston, Massachusetts. The major objective was to obtain, as quickly as possible, information on the frequency of major malformations among infants whose mothers had taken one or more AEDs to prevent seizur...
متن کاملAntiepileptic drug use during pregnancy: Perinatal outcomes
PURPOSE This study was undertaken to (1) measure the frequency of AED monotherapy or polytherapy during pregnancy and AED discontinuation prior to pregnancy in a cohort of women with treated epilepsy; and (2) describe the frequency of major congenital malformations according to maternal use of AED during pregnancy. METHODS A cohort of epileptic pregnant women was identified within the Quebec ...
متن کاملAntiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data.
BACKGROUND Antiepileptic drugs (AEDs) are used by pregnant women to manage conditions such as epilepsy and bipolar disorder even though they pose a risk to the developing foetus. This study aimed to determine the overall use of AEDs by women during their childbearing years and women who are pregnant and the association between AED use and rates of pregnancy termination and spontaneous abortion....
متن کاملTreatment With Antipsychotics in Pregnancy: Changes in Drug Disposition
Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic drug monitoring concentration measurements obtained from a total of 110 pregnancies in 103 women, and 512 measurements from the same women before and after pregnancy. Serum...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2013
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-27-6-2